Are you struggling with persistent numbness, tingling, or burning pain in your hands or feet? If so, you may be dealing with peripheral neuropathy—a condition that affects the nerves outside the brain and spinal cord. This can be frustrating, debilitating, and have a major impact on your quality of life.

While it’s essential to work with your doctor to uncover the root cause, many people also wonder what they can do right now to find relief. Supplements are not a cure-all, but research shows that certain ones can reduce nerve irritation, calm inflammation, and support healthier nerve function.

Two Important Disclaimers

1. Always consult your doctor first. Supplements can interact with medications and health conditions. Starting one without medical guidance can be risky.

2. There is no instant cure. True healing takes time and consistency. Supplements may help reduce symptoms and improve nerve health, but they are part of a broader strategy—not a quick fix.

The Top 5 Supplements for Peripheral Neuropathy

5. N-Acetylcysteine (NAC)

NAC is derived from the amino acid L-cysteine and naturally occurs in foods like beans, lentils, and bananas. It helps by suppressing inflammatory enzymes that worsen nerve damage.

• What research shows: Clinical studies suggest NAC can reduce pain and debility in neuropathy by calming nerve inflammation.
• Typical dosage in studies: 600–1,200 mg daily.
• Key point: NAC is promising but should be taken under medical supervision.

4. Omega-3 Fatty Acids

Omega-3s are essential fats with wide-ranging benefits. Beyond improving heart and brain health, they may protect nerves and even promote regeneration after damage.

• What research shows: Both animal and human studies demonstrate reductions in neuropathic pain.
• Sources: Cold-water fish (salmon, sardines, cod), flax seeds, chia seeds, walnuts.
• Typical dosage in studies: 1–3 grams daily.
• Caution: High doses may thin the blood and slightly increase atrial fibrillation risk.

3. Acetyl-L-Carnitine (ALCAR)

ALCAR is an amino acid that supports cellular energy production and nerve communication.

• What research shows: Multiple high-quality clinical trials demonstrate significant pain relief and improved nerve function, especially in diabetic neuropathy.
• Typical dosage in studies: 2–3 grams daily.
• Key point: One of the most scientifically supported options for nerve pain.

2. Curcumin

Curcumin, the active compound in turmeric, is a potent anti-inflammatory with a long history in traditional medicine.

• What research shows: Curcumin inhibits inflammatory pathways linked to nerve pain. Some studies suggest it can be as effective as NSAIDs for pain management.
• Absorption tip: Look for supplements with piperine (BioPerine) from black pepper, which boosts absorption by up to 2,000%.
• Typical dosage in studies: 500 mg–2 grams daily.

1. Alpha-Lipoic Acid (ALA)

ALA is the most well-researched and proven supplement for peripheral neuropathy.

• What research shows: Multiple clinical trials confirm ALA reduces tingling, burning, and numbness, particularly in diabetic neuropathy.
• How it works: Improves blood flow to nerve tissue, reduces oxidative stress, and protects nerve cells from damage.
• Typical dosage in studies: 600–1,800 mg daily. Significant benefits have been seen in as little as 3 weeks at 600 mg/day.

Conclusion

Peripheral neuropathy is challenging, but you do have options to support your body and reduce symptoms. The five supplements with the strongest evidence are:

Remember: Supplements are tools, not cures. They work best when integrated into a comprehensive care plan—under the guidance of a healthcare professional who understands your medical history. By taking proactive steps and having informed conversations with your doctor, you can move closer to reduced pain, healthier nerves, and a more active life.